Taking etodolac and cyclosporine together may increase your risk of kidney damage.
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In patients with renalcardiac or hepatic impairment especially those taking diuretics and the elderlyrenal function should be monitored in these patientssee also section 4.3Caution is required since the use of NSAIDs may result in a dose dependent reduction in prostaglandin formation and precipitate renal failureThe dose should be kept as low as possibleHoweverimpairment of renal or hepatic functions due to other causes may alter drug metabolismpatients receiving concomitant long term therapyespecially the elderlyshould be observed for potential side effects and their drug doses adjusted as neededor the drug discontinued.
History of gastrointestinal bleeding or perforationrelated to previous NSAIDs therapy.
Serious gastrointestinal adverse effects such as bleedingulceration and perforationwhich can be fatalhas been reported and can occur at any time with or without warning symptoms in patients treated with NSAIDs or a previous history of serious GI eventsIf any sign of gastrointestinal bleeding occursLodine should be stopped immediately.
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