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Concomitant use of SARAFEMfluoxetinein patients taking MAOIs is contraindicatedThere have been reports of serioussometimes fatalreactionsincluding hyperthermiarigiditymyoclonusautonomic instability with possible rapid fluctuations of vital signsand mental status changes that include extreme agitation progressing to delirium and comain patients receiving fluoxetine in combination with a monoamine oxidase inhibitorMAOIand in patients who have recently discontinued fluoxetine and are then started on an MAOISome cases presented with features resembling neuroleptic malignant syndromeThereforefluoxetineincluding SARAFEMshould not be used in combination with an MAOIor within a minimum of 14 days of discontinuing therapy with an MAOIsee CONTRAINDICATIONSSince fluoxetine and its major metabolite have very long elimination half-livesat least 5 weeksperhaps longerespecially if fluoxetine has been prescribed chronically and/or at higher dosesshould be allowed after stopping fluoxetine before starting an MAOIsee DOSAGE AND ADMINISTRATIONCONTRAINDICATIONSWARNINGS AND PRECAUTIONSand CLINICAL PHARMACOLOGY
Preferred drug of choice in elderly over tricyclic antidepressants because of fewer side effects.
Since untreated mental/mood problemssuch as depressionpanic attacksobsessive compulsive disordercan be a serious conditiondo not stop taking this medication unless directed by your doctorIf you are planning pregnancybecome pregnantor think you may be pregnantimmediately discuss the benefits and risks of using this medication during pregnancy with your doctor.
SARAFEM has the potential to impair judgmentthinkingor motor skillsPatients should be cautioned about operating hazardous machineryincluding automobilesuntil they are reasonably certain that the drug treatment does not affect them adversely.
As with other SSRIsdecreased weight gain has been observed in association with the use of fluoxetine in children and adolescent patientsAfter 19 weeks of treatment in a clinical trialpediatric subjects treated with fluoxetine gained an average of 1.1 cm less in height and 1.1 kg less in weight than subjects treated with placeboIn additionfluoxetine treatment was associated with a decrease in alkaline phosphatase levelsThe safety of fluoxetine treatment for pediatric patients has not been systematically assessed for chronic treatment longer than several months in durationIn particularthere are no studies that directly evaluate the longer-term effects of fluoxetine on the growthdevelopment and maturation of children and adolescent patientsThereforeheight and weight should be monitored periodically in pediatric patients receiving fluoxetinesee WARNINGS AND PRECAUTIONS
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brand names for fluoxetine include prozac, and sarafem.