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Do not use bupropion within 14 days before or 14 days after you have used a MAO inhibitorsuch as isocarboxazidlinezolidmethylene blue injectionphenelzinerasagilineselegilineor tranylcypromine.
Studies in rodents and primates have shown that bupropion exhibits some pharmacologic actions common to psychostimulantsIn rodentsit has been shown to increase locomotor activityelicit a mild stereotyped behavioral responseand increase rates of responding in several schedule-controlled behavior paradigmsIn primate models to assess the positive reinforcing effects of psychoactive drugsbupropion was self-administered intravenouslyIn ratsbupropion produced amphetamine-like and cocaine-like discriminative stimulus effects in drug discrimination paradigms used to characterize the subjective effects of psychoactive drugs.
In clinical practicehypertensionin some cases severerequiring acute treatmenthas been reported in patients receiving bupropion alone and in combination with nicotine replacement therapyThese events have been observed in both patients with and without evidence of preexisting hypertension.
Finallyit is important to emphasize that the tabulation does not reflect the relative severity and/or clinical importance of the eventsA better perspective on the serious adverse events associated with the use of bupropion is provided in the WARNINGS and PRECAUTIONS sections.
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