Most cases of dvt can be successfully treated with a combination of medications, including heparin or lovenox and then coumadin warfarin or possibly one of the newer drugs such as or similar to pradaxa.
Information about Coumadin.
NoteThis document contains side effect information about warfarinSome of the dosage forms listed on this page may not apply to the brand name Coumadin.
Clinical factors including ageracebody weightsexconcomitant medicationsand comorbidities Genetic factorsCYP2C9 and VKORC1 genotypessee CLINICAL PHARMACOLOGY
In a prospectiverandomizedopen-labelpositive-controlled study in 254 patients with mechanical prosthetic heart valvesthe thromboembolic-free interval was found to be significantly greater in patients treated with warfarin alone compared with dipyridamole/aspirin-treated patientsp.
But the tablet shape may be differentlike oval or squareif you change brands.
The S-enantiomer of warfarin is mainly metabolized to 7-hydroxywarfarin by CYP2C9a polymorphic enzymeThe variant allelesCYP2C9*2 and CYP2C9*3result in decreased in vitro CYP2C9 enzymatic 7-hydroxylation of S-warfarinThe frequencies of these alleles in Caucasians are approximately 11and 7for CYP2C9*2 and CYP2C9*3respectively.
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