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Celebrex may be used during the different inflammatory diseases of non-infectious origin, but this drug provides the highest activity during .

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Consider alternative management in patients who are poor CYP2C9 metabolizers.

The effects of celecoxib on the pharmacokinetics and/or pharmacodynamics of glyburideketoconazolesee DRUG INTERACTIONSphenytoinand tolbutamide have been studied in vivo and clinically important interactions have not been found.

The effects of celecoxib on the pharmacokinetics and/or pharmacodynamics of glyburideketoconazolesee DRUG INTERACTIONSphenytoinand tolbutamide have been studied in vivo and clinically important interactions have not been found.

Symptoms following acute NSAID overdosages have been typically limited to lethargydrowsinessnauseavomitingand epigastric painwhich have been generally reversible with supportive careGastrointestinal bleeding has occurredHypertensionacute renal failurerespiratory depressionand coma have occuredbut were raresee WARNINGS AND PRECAUTIONS

Inform patients of the signs of an anaphylactic reactione.gdifficulty breathingswelling of the face or throatInstruct patients to seek immediate emergency help if these occursee CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS

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celebrex is indicated for relief of the signs and symptoms of osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis in patients 2 years and older and ankylosing spondylitis.

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