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Losartan selectively blocks the AT 1 receptorIn vitro and in vivo losartan and its pharmacologically active carboxylic acid metabolite E-3174 block all physiologically relevant actions of angiotensin IIregardless of the source or route of its synthesis.
Losartan is not recommended in children with glomerular filtration rate 2 as no data are availablesee section 4.2
The frequency of adverse reactions listed below is defined using the following convention:
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