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Be careful when driving or operating machinery until you know how SINEMET affects you.

Parkinson’s disease is a progressiveneurodegenerative disorder of the extrapyramidal nervous system affecting the mobility and control of the skeletal muscular systemIts characteristic features include resting tremorrigidityand bradykinetic movementsSymptomatic treatmentssuch as levodopa therapiesmay permit the patient better mobility.

The incidence of levodopa-induced nausea and vomiting is less with SINEMET than with levodopaIn many patientsthis reduction in nausea and vomiting will permit more rapid dosage titration.

SINEMET is indicated in the treatment of Parkinson’s diseasepost-encephalitic parkinsonismand symptomatic parkinsonism that may follow carbon monoxide intoxication or manganese intoxication.

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