Tinidazole 2 g single oral dose use in trichomoniasis has been well documented in 34 published reports from the world literature involving over 2,800 patients treated with tinidazole.
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Central Nervous SystemTwo serious adverse reactions reported include convulsions and transient peripheral neuropathy including numbness and paresthesiasee WARNINGS AND PRECAUTIONSOther CNS reports include vertigoataxiagiddinessinsomniadrowsiness.
Tinidazole is indicated for the treatment of giardiasis caused by Giardia duodenalisalso termed Glambliain both adults and pediatric patients older than three years of agesee Clinical StudiesSections or subsections omitted from the full prescribing information are not listed.
There are several case reports suggesting that metronidazole has the potential to increase the levels of cyclosporine and tacrolimusDuring tinidazole co-administration with either of these drugsthe patient should be monitored for signs of calcineurin-inhibitor associated toxicities.
Alcoholic beverages and preparations containing ethanol or propylene glycol should be avoided during tinidazole therapy and for 3 days afterward because abdominal crampsnauseavomitingheadachesand flushing may occurPsychotic reactions have been reported in alcoholic patients using metronidazole and disulfiram concurrentlyThough no similar reactions have been reported with tinidazoletinidazole should not be given to patients who have taken disulfiram within the last two weeks.
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