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Herbal preparations containing StJohn’s Wort and Viramune must not be co-administeredsee section 4.3If a patient is already taking StJohn’s Wort check nevirapine and if possible viral levels and stop StJohn’s WortNevirapine levels may increase on stopping StJohn’s WortThe dose of Viramune may need adjustingThe inducing effect may persist for at least 2 weeks after cessation of treatment with StJohn’s Wort.

Coadministration with herbal preparations containing StJohn’s wortHypericum perforatumdue to the risk of decreased plasma concentrations and reduced clinical effects of nevirapinesee section 4.5

Viramune is indicated in combination with other anti-retroviral medicinal products for the treatment of HIV-1 infected adultsadolescentsand children of any agesee section 4.2

To support the use of the prolonged-release tabletsthe company conducted studies to show that the immediateand prolonged-release tablets both had adequate drug levelsand the same effect on the viral load in the bodyStudies were also done to show successful switching from immediate-release tabletstwice daily to prolonged-release tabletsonce daily.

Coadministration with herbal preparations containing StJohn’s wortHypericum perforatumdue to the risk of decreased plasma concentrations and reduced clinical effects of nevirapinesee section 4.5

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